LENVIMA dosing and administration

Once a day. Every day. With or without food¹

Recommended LENVIMA dose: 8 mg (two 4-mg capsules) for a patient weighing less than 132 lb (<60 kg), and 12 mg (three 4-mg capsules) for a patient weighing 132 lb or more (≥60 kg).¹

Preparation of suspension:

• Place the required number of capsules, up to a maximum of 5, in a small container (approximately 20 mL capacity) or syringe (20 mL). Do not break or crush capsules
• Add 3 mL of liquid to the container or syringe. Wait 10 minutes for the capsule shell (outer surface) to disintegrate, then stir or shake the mixture for 3 minutes until capsules are fully disintegrated and administer the entire contents
• Next, add an additional 2 mL of liquid to the container or syringe using a second syringe or dropper, swirl or shake and administer. Repeat this step at least once and until there is no visible residue to ensure all of the medication is taken
• If 6 capsules are required for a dose, follow these instructions using 3 capsules at a time

If LENVIMA suspension is not used at the time of preparation, LENVIMA suspension may be stored in a refrigerator at 36°F to 46°F (2°C to 8°C) for a maximum of 24 hours in a covered container. If not administered within 24 hours, the suspension should be discarded.

Note: Compatibility has been confirmed for polypropylene syringes and for feeding tubes of at least 5 French diameter (polyvinyl chloride or polyurethane tube) and at least 6 French diameter (silicone tube).

Continue LENVIMA until disease progression or unacceptable toxicity.¹

Hepatic impairment¹

• No dose adjustment is recommended for patients with HCC and mild hepatic impairment
  (Child-Pugh A)
• There is no recommended dose for patients with HCC with moderate (Child-Pugh B) or severe (Child-Pugh C) hepatic impairment

Renal impairment¹

• No dose adjustment is recommended for patients with mild (creatinine clearance 60-89 mL/min) or moderate (creatinine clearance 30-59 mL/min) renal impairment
• There is no recommended dose of LENVIMA for patients with HCC and severe renal impairment
• LENVIMA has not been studied in patients with end-stage renal disease

Missed doses of LENVIMA¹

• LENVIMA should be taken at the same time each day
• If a dose is missed and cannot be taken within 12 hours, skip that dose and take the next dose at the usual time of administration

HCC=hepatocellular carcinoma.