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LENVIMA® (lenvatinib) capsules 10 mg and 4 mg logo
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RAI-refractory DTC 1st-Line treatment of aRCC 2nd-Line treatment of aRCC 1st-Line treatment of uHCC Advanced EC
LENVIMA® for adult patients with locally recurrent or metastatic, progressive, radioactive iodine-refractory differentiated thyroid cancer

Mechanism of action (MOA) of LENVIMA

LENVIMA is thought to block receptors required for tumor growth and blood vessel development1

LENVIMA MOA graphic
  • LENVIMA is a kinase inhibitor that inhibits the kinase activities of vascular endothelial growth factor receptors (VEGFRs): VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4)2
  • LENVIMA inhibits other kinases (including FGFR1, 2, 3, and 4; PDGFRA, KIT, and RET) that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progression, in addition to their normal cellular functions2

VEGF=vascular endothelial growth factor; FGF=fibroblast growth factor; FGFR=fibroblast growth factor receptor; FLT=Fms-related tyrosine; KDR=kinase insert domain receptor; PDGFRA=platelet-derived growth factor receptor alpha; RET=rearranged during transfection.

Find additional LENVIMA resource materials
AR Management Resource Library